Fig 1: The malignant behaviors of EDIL3 in GC.(A) EDIL3 mRNA expression in AGS and BGC-823 cells after sh-RNA transfection. (B) The cell viability of AGS and BGC-823 cells measured by CCK-8 after sh-RNA transfection. (C) Colony formation assay of AGS and BGC-823 cells after sh-RNA transfection. (D)The migration and invasion assays of AGS and BGC-823 cells after sh-RNA transfection. Scale bars, 100 µm.
Fig 2: The EDIL3 co-expression genes in GC.(A) Volcano map of co-expressed genes of EDIL3 in GC cohort. (B) Heat map of the top 50 genes positively associated with EDIL3. (C) Heat map of the top 50 genes negatively associated with EDIL3. Red represents positively linked genes and blue represents negatively linked genes. (D) Survival map of the top 50 genes positively and negatively associated with EDIL3 in GC using GEPIA. The red and blue squares indicate higher and lower risks for survival, respectively. The bordered squares indicate the significant unfavorable and favorable survival (P < 0.05). (E) EDIL3 co-expression genes were categorized for GO analysis in GC cohort. (F) EDIL3 co-expression genes were categorized for KEGG pathway analysis in GC cohort.
Fig 3: The prognostic significance of EDIL3 in GC.(A) Survival analysis of EDIL3 expression in 152 GC patients after curative resection. (B) Survival analysis of the EDIL3 expression in GC patients by HPA database. (C) Survival analysis of the EDIL3 expression in GC patients by Kaplan–Meier plotter database. (D) Univariate analysis of parameters correlated with OS of GC patients. (E) Multivariate analysis of parameters correlated with OS of GC patients.
Fig 4: The relationship of EDIL3 expression with immune infiltration in GC.(A) The relationship between EDIL3 expression and immune cell enrichment in GC through ssGSEA algorithm. The size of the dots represents the absolute Spearman’s correlation coefficient values. (B) The relationship between EDIL3 expression and immune infiltration in GC from TIMER. (C) The relationship between risk score and different immune features in TCGA cohort. (* P < 0.05, ** P < 0.01, *** P < 0.001).
Fig 5: Prognostic significance of EDIL3 expression in immune cell subgroups in GC.(A) The association between EDIL3 and OS in different immune cell subgroups in GC. Relationships between EDIL3 expression and OS in GC base on enriched or decreased CD8+ T cell (B), natural killer T cell (C), regulatory T cell (D), type 2 T helper cell (E), B cell (F), and macrophage (G) subgroups.
Supplier Page from Abcam for Anti-EDIL3/DEL1 antibody